EDUCATIONAL CORNER
Recommendations to improve use and reporting of statistics in animal experiments
December 22, 2023Flaws in experimental statistics are a major contributor to the poor reproducibility of animal experiments. Informed decisions about whether conclusions are…
Read MoreCo-creating Research Integrity Education Guidelines for Research Institutions
December 22, 2023To support institutions to foster research integrity (RI), Krishma Labib and colleagues developed RI education guidelines together with RI experts and…
Read MoreCell line authentication: a necessity for reproducible biomedical research
November 2, 2022Immortalized or continuous cell lines are invaluable tools in basic and preclinical research. However, the widespread use of misidentified cell lines…
Read MoreDesigning and implementing a research integrity promotion plan: Recommendations for research funders
November 2, 2022Various stakeholders in science have put research integrity high on their agenda. Among them, research funders are prominently placed to foster…
Read MoreThe EQIPD Framework
September 6, 2022The EQIPD framework for rigor in the design, conduct, analysis, and documentation of animal experiments was published today. It defines the demands for…
Read MoreBringing microscopy images to the next level
June 16, 2022In this Nature Methods issue, the global microscopy community presented comprehensive efforts to improve reporting and reproducibility of microscopy images. Articles…
Read MoreThe MDAR (Materials Design Analysis Reporting) Framework for transparent reporting in the life sciences
March 14, 2022The MDAR working group came together in late 2017 with the intention to develop a framework to promote transparent reporting, with…
Read MoreToward Standardized Guidelines for Investigating Neural Circuit Control of Behavior in Animal Research
November 3, 2021With the advent of tools for recording and manipulating activity with high spatiotemporal resolution in defined neural circuits in behaving animals,…
Read MorePAASP publication in Nature Reviews Drug Discovery: Improving target assessment in biomedical research – the GOT-IT recommendations
December 18, 2020The PAASP team has published an article in Nature Reviews Drug Discovery, together with research groups from the Fraunhofer IME-TMP and the…
Read MoreGuidelines for target validation published
November 16, 2020The GOT-IT team, consisting of researchers from the Fraunhofer Institute, Charité and PAASP, announces the publication of their guidelines for target validation…
Read MoreThe Hong Kong Principles for assessing researchers: Fostering research integrity
August 17, 2020For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages…
Read MoreImpact of tumour heterogeneity and tissue sampling for genetic mutation testing: a systematic review and post hoc analysis
August 17, 2020Staff at QED Biomedical Ltd have conducted research to demonstrate how sample bias in patient- derived tumour tissue samples with somatic…
Read MoreSystematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals
May 28, 2020Several initiatives have set out to increase transparency and internal validity of preclinical studies. While many of the points raised in…
Read MoreImproving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative
March 31, 2020The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists,…
Read MoreNew Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology
February 1, 2020To improve the robustness and transparency of scientific reporting, the American Society for Pharmacology and Experimental Therapeutics (ASPET), with input from PAASP’s Martin…
Read MoreA consensus-based transparency checklist
December 18, 2019Transparency of research processes is required not only for evaluating and reproducing results, but also for research synthesis and meta-analysis from…
Read MoreARRIVE 2.0
November 22, 2019A long-awaited revision of the ARRIVE guidelines has finally been published (The ARRIVE guidelines 2019).What impact can we expect from ARRIVE…
Read MoreToward Good In Vitro Reporting Standards
November 22, 2019Many areas of biomedical science have developed reporting standards and checklists to support the adequate reporting of scientific efforts, but in…
Read MoreNew Handbook of Experimental Pharmacology focusing on Good Research Practice
November 22, 2019The Handbook of Experimental Pharmacology is one of the most authoritative and influential book series in pharmacology. It provides critical and…
Read MoreGood Practice for Conference Abstracts and Presentations: GPCAP
August 12, 2019GPCAP provides recommendations on good submission and presentation practice for scientific and medical congresses. These recommendations cover conference abstracts, posters and…
Read MoreWilling to test ARRIVE guidelines?
August 12, 2019The NC3R is looking for volunteers to test and share experience about the newly published ARRIVE guidelines. Testing newly developed guidelines…
Read MoreUpdated Arrive guidelines 2019
July 18, 2019A long awaited revision of the ARRIVE guidelines has finally been published. There are three main reasons why the revision was…
Read MoreTo Have Practical Relevance, Scientific Claims Need to be Accurate
September 10, 2018For all different stakeholders within the scientific community (researchers, reviewers, editors, policymakers, funding agencies, journalists, and the general public) it is…
Read MoreGuidelines on statistics for researchers using laboratory animals: the essentials
September 10, 2018There is a growing concern that flawed statistics and deficient reproducibility in biomedical studies results in an unethical waste of animals…
Read MoreA randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)
September 10, 2018The ARRIVE guidelines are widely endorsed but compliance is limited. The IICARus Collaboration group sought to determine whether journal-requested completion of…
Read MoreUnambiguous identification of antibodies, cell lines and organisms around the globe: A call for the Research Resource ID
August 21, 2018Unambiguous identification of antibodies, cell lines and organisms around the globe: A call for the Research Resource ID The reproducibility crisis…
Read MoreFAIR and ALCOAplus – data management principles
August 13, 2018Data recording practices play a central element in research and can vary largely from lab to lab and researcher to researcher….
Read MoreNewly developed ‘Harmonized animal research reporting principles’ (HARRP) published
July 9, 2018The International Council for Laboratory Animal Science (ICLAS) has recently published Harmonized Animal Research Reporting Principles (HARRP), the first step of…
Read MoreImproving animal research reporting standards
June 6, 2018For decades, scientists and organizations have expressed concerns about the quality of animal research reporting. These concerns and efforts to establish…
Read MorePREPARE (Planning Research and Experimental Procedures on Animals: Recommendations for Excellence) Guidelines
March 30, 2018As part of ongoing efforts to reduce waste and increase the reproducibility of animal research and testing, a group of experts…
Read MorePREPARE: guidelines for planning animal research and testing
February 26, 2018The PREPARE (Planning Research and Experimental Procedures on Animals: Recommendations for Excellence) guidelines were published in 2017 to provide overarching guidance on…
Read MoreStudy Design
August 17, 2017These articles are presenting ideas on how to improve experiments. Howells, DW et al. 2014. “Bringing rigour to translational medicine.” Nature…
Read More“The TOP Guidelines”
July 21, 2017Guidelines for Transparency and Openness Promotion (TOP) in Journal Policies and Practices which are published by the Center for Open Science…
Read MoreNosek et al., 2015 Science
July 21, 2017Brian Nosek et al. present in this communication an informative introduction to standards set-up by the Transparency and Openness Promotion (TOP)…
Read MoreThe Committee on Publication Ethics (COPE)
July 21, 2017The Committee on Publication Ethics was established in 1997 and has grown to over 10000 members. It provides advice on publication…
Read MoreRIGOR guidelines
July 21, 2017Comprehensive guidelines especially designed for research in animal models of stroke. However, it does contain basic aspects that can be applied…
Read MoreMIFlowCyt guidelines
July 21, 2017Lee et al., 2008 Journal of the International Society for Advancement of Cytometry (“MIFlowCyt”) Guidelines about the Minimum Information a Flow…
Read MoreSteckler et al. 2016 editorial in psychopharmacology
July 21, 2017These recently published guidelines for the Journal of Psychopharmacology are a great example on information to be reported with animal experiments.
Read MoreSimera et al., 2010 Eur J of Clin Invest
July 21, 2017Introduction to the EQUATOR Network, which provides resources, education and training to facilitate good research reporting and assists in the development,…
Read MoreBravo et al., 2015 BMC Medicine
July 21, 2017Guideline on how to cite bioresources (CoBRA). LINK
Read MoreMoher et al., 2015 BMC Medicine
July 21, 2017Overview of published guidelines on reporting preclinical research. LINK
Read MoreIoannidis and Khoury, 2014 JAMA
July 21, 2017In this viewpoint the assessing value in biomedical research is discussed based on research that is Productive, High-quality, Reproducible, Shareable and…
Read MoreGuidelines by the European Science Foundation (ESF)
July 21, 2017The European Code of Conduct for Research Integrity Intended to provide an europe-wide reference, this code addresses the proper conduct and…
Read MoreSteward and Balice-Gordon, 2014 Neuron
July 21, 2017Review of best practices and presentation of new guidelines with a focus on preclinical studies relevant to human neurological and psychiatric…
Read MoreWHO quality practices
July 21, 2017The WHO provides in this handbook guidance for research institutions and individual researchers to improve the quality of their research data….
Read MoreGSP document by DFG
July 21, 2017Proposal for Safeguarding Good Scientific Practice by the German Research Foundation (DFG). The first recommendations were published in 1997 with an…
Read MoreMIATA guidelines
June 26, 2017This webpage provides useful information on how to publish data derived from flow cytometry experiments in particular when analysing T-cells and…
Read MoreSTROBE Statement
June 26, 2017“STROBE stands for an international, collaborative initiative of epidemiologists, methodologists, statisticians, researchers and journal editors involved in the conduct and dissemination…
Read MoreARRIVE guidelines 2010
June 26, 2017NEW guidelines are available: Updated Arrive guidelines These guidelines were presented by the National Centre for the Replacement, Refinement and Reduction of…
Read MoreAre ‘Secret’ Software Codes part of the reproducibility crisis?
June 7, 2017A commentary based on the two articles by Jiménez et al. and Eglen et al. about the need to publish the…
Read MoreWebinar: ‘GRADE for preclinical animal studies: translating evidence from bench to bedside’
May 19, 2017Laboratory animal studies are used in a wide range of human health related research areas. The results of these studies can…
Read MoreA STAR Is Born
August 25, 2016A STAR Is Born – Cell Press transforms the methods section of articles to improved transparency and accessibility. As one of the…
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